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Piceatannol (CAS 10083-24-6)

Alternate Names:  astringinin; 3-Hydroxyresveratol; 3,5,3',4'-Tetrahydroxystilbene
Application:  Piceatannol is an inhibitor of Syk and NF-κB activation
CAS Number:  10083-24-6
Purity: >98%
Molecular Weight: 244.24
Molecular Formula:  C14H12O4

Prices Quote USD: 

25 mg: $200 
50 mg: $350
10 mg: $600
20 mg: $1000
50 mg: $2300
100 mg: $3000

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Product Description
Piceatannol is a catechol-type polyphenol. The compound has been shown to act as a protein-tyrosine kinase inhibitor, and preferentially inhibits Syk in comparison to Lyn in in vitro kinase assays. In MCF-10A cell studies, Piceatannol inhibited phorbol ester-induced NF-κB activation and cyclooxygenase-2 expression. Research indicates that Piceatannol can upregulate Fas and FasL through AFT2 and Ca2+/p38α MAPK-mediated activation of c-Jun pathways. Identified as a potential inhibitor of PKA, PKC, MYLK, Lck, and IKKβ as well as an activator of SIRT1. SIRT1 is an NAD+ dependent deacetylase that is known to target histone H4. Piceatannol is an inhibitor of CaMK, JNK, IKKα and PI 3-kinase. Piceatannol is an activator of caspase-3.

Technical Information
Appearance : Powder
Physical State :  Solid
Derived From :   Synthetic
Solubility :  Soluble in DMSO (10 mg/ml), DMF, ethanol (10 mg/ml), methanol, acetone, ethyl acetate, and water (0.5 mg/ml).
Storage :   Store at -20° C
Melting Point :   235° C (lit.)(dec.)
Boiling Point :  108° C (lit.) at 0.04 mmHg
Density :   ~1.5 g/cm3 (Predicted)
Refractive Index :  n20D 1.80
IC50 :protein tyrosine kinase Syk: IC50 = ~10 µM; protein kinase A catalytic subunit: IC50 = 3 µM (rat liver); PKC: IC50 = 8 µM; MLCK: IC50 = 12 µM; Ca2+-dependent protein kinase (CDPK): IC50 = 19 µM (wheat embryo)


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