Piceatannol is a catechol-type polyphenol. The compound has been shown to act as a protein-tyrosine kinase inhibitor, and preferentially inhibits Syk in comparison to Lyn in in vitro kinase assays. In MCF-10A cell studies, Piceatannol inhibited phorbol ester-induced NF-κB activation and cyclooxygenase-2 expression. Research indicates that Piceatannol can upregulate Fas and FasL through AFT2 and Ca2+/p38α MAPK-mediated activation of c-Jun pathways. Identified as a potential inhibitor of PKA, PKC, MYLK, Lck, and IKKβ as well as an activator of SIRT1. SIRT1 is an NAD+ dependent deacetylase that is known to target histone H4. Piceatannol is an inhibitor of CaMK, JNK, IKKα and PI 3-kinase. Piceatannol is an activator of caspase-3.
Appearance : Powder
Physical State : Solid
Derived From : Synthetic
Solubility : Soluble in DMSO (10 mg/ml), DMF, ethanol (10 mg/ml), methanol, acetone, ethyl acetate, and water (0.5 mg/ml).
Storage : Store at -20° C
Melting Point : 235° C (lit.)(dec.)
Boiling Point : 108° C (lit.) at 0.04 mmHg
Density : ~1.5 g/cm3 (Predicted)
Refractive Index : n20D 1.80
IC50 :protein tyrosine kinase Syk: IC50 = ~10 µM; protein kinase A catalytic subunit: IC50 = 3 µM (rat liver); PKC: IC50 = 8 µM; MLCK: IC50 = 12 µM; Ca2+-dependent protein kinase (CDPK): IC50 = 19 µM (wheat embryo)