Methaqualone is a substance once prescribed as a sedative and hypnotic medication, under the brand names Quaalude and Mandrax among others, until commercial production was halted due to widespread abuse, among other things. It is a member of the quinazolinone class.
Molar mass: 250.3 g/mol
CAS ID: 72-44-6
Elimination half-life: Biphasic (10-40; 20-60 hours)
Melting point: 113 °C (235 °F)
Prices Quote in Grams:
50g: $800 / 100g: $1400
250g: $2900 / 500g: $5000
1000g: $8000 / 2000g $14200
Methaqualone is a sedative that increases the activity of the GABA receptors in the brain and nervous system, similarly to benzodiazepines and barbiturates. When GABA activity is increased, blood pressure drops and breathing and pulse rates slow, leading to a state of deep relaxation. These properties explain why methaqualone was originally mainly prescribed for insomnia.
Methaqualone was not recommended for use while pregnant and is in pregnancy category D.
An overdose can lead to nervous system shutdown, coma and death. Additional effects are delirium, convulsions, hypertonia, hyperreflexia, vomiting, kidney failure, coma, and death through cardiac or respiratory arrest. It resembles barbiturate poisoning, but with increased motor difficulties and a lower incidence of cardiac or respiratory depression. The standard single tablet adult dose of Quaalude brand of methaqualone was 300 mg when made by Lemmon. A dose of 8000 mg is lethal and a dose as little as 200 mg could induce a coma if taken with an alcoholic beverage.[5